Recombinant Human HEYL, His-tagged

• Cat.No.: HEYL-13757H
• Product Overview: Recombinant Human HEYL protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-328a.a.
• Description: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HEYL hairy/enhancer-of-split related with YRPW motif-like [ Homo sapiens ]
• Official Symbol: HEYL
• Synonyms: HEYL; hairy/enhancer-of-split related with YRPW motif-like; hairy/enhancer-of-split related with YRPW motif-like protein; bHLHb33; hairy/enhancer of split related with YRPW motif 3; HEY3; HRT-3; hHRT3; hHeyL; HEY-like protein; hairy-related transcription factor 3; class B basic helix-loop-helix protein 33; hairy/enhancer-of-split related with YRPW motif 3; HRT3; MGC12623
• Gene ID: 26508
• mRNA Refseq: NM_014571
• Protein Refseq: NP_055386
• MIM: 609034
• UniProt ID: Q9NQ87
• Chromosome Location: 1p34.3
• Pathway: NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem
• Function: AF-1 domain binding; DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding