Recombinant Human Heme Oxygenase (Decycling) 2, GST-tagged

• Cat.No.: HMOX2-1453H
• Product Overview: Recombinant full-length human HO2 Protein was expressed inE. colicells using an N-terminal GST tag. MW = 62 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: HO2, or heme oxygenase 2, belongs to the heme oxygenase family that are essential enzyme in heme catabolism that cleave heme to form biliverdin which is subsequently converted to bilirubin by biliverdin reductase. HO2 is part of the calcium-sensitive potassium channel complex and enhances channel activity in normoxia. Knockdown of HO2 expression reduces channel activity, an effect that is reversed by carbon monoxide. Inhibition of calcium-sensitive potassium channels by hypoxia is dependent on HO2 expression and is augmented by HO2 stimulation.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: HMOX2 heme oxygenase (decycling) 2 [ Homo sapiens ]
• Synonyms: HMOX2; heme oxygenase (decycling) 2; HO-2; EC 1.14.99.3; HO2; heme oxygenase (decyclizing) 2; Heme oxygenase 2
• Gene ID: 3163
• mRNA Refseq: NM_001127204
• Protein Refseq: NP_001120676
• MIM: 141251
• UniProt ID: P30519
• Chromosome Location: 16p13.3
• Pathway: Porphyrin and chlorophyll metabolism
• Function: electron carrier activity; heme oxygenase (decyclizing) activity; iron ion binding; metal ion binding; oxidoreductase activity; protein binding