Hmox2
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Official Full Name
heme oxygenase (decycling) 2 -
Overview
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013] -
Synonyms
HMOX2;heme oxygenase (decycling) 2;HO-2;heme oxygenase 2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Cynomolgus
- E.coli
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- Non
- GST
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Hmox2 involved in several pathways and played different roles in them. We selected most pathways Hmox2 participated on our site, such as Porphyrin and chlorophyll metabolism,Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hmox2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Porphyrin and chlorophyll metabolism | ALAS2,UGT2A1,HCCSB,FXN,HMOX1,EARS2,UGT2A2,UGT1A4,MMAB,HCCSA.1 |
| Mineral absorption | MT1,SLC26A6,ATP1A4,MT1E,FTL,ATP1A3,HEPH,MT2,ATP1A2,SLC40A1 |
Protein Function
Hmox2 has several biochemical functions, for example, heme oxygenase (decyclizing) activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Hmox2 itself. We selected most functions Hmox2 had, and list some proteins which have the same functions with Hmox2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAGEA11,TSSK1,PSAP,FGFR1OP2,PRSS3,SLPI,APOBEC3H,TOLLIP,TIFA,GATA6 |
| metal ion binding | ZNF830,WBSCR17,UQCRC2A,ADCY9,ANKIB1A,HNRNPA0L,NANOS1,FREM2,PGCP,TRIM35-19 |
| heme oxygenase (decyclizing) activity | HMOX1,HMOX2A,HMOX1B,HMOX1A |
Interacting Protein
Hmox2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hmox2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hmox2.
HAP1;CEP126;GIT1;USP19;PLXNB2;NKRF;NDUFS2;A2M;NR3C1;ATP5B;EEF1G;SHC1;CEBPZ;RBBP4;SETDB1;IMMT;RIF1
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References
- Lonati, C; Sordi, A; et al. Molecular Changes Induced in Rat Liver by Hemorrhage and Effects of Melanocortin Treatment. ANESTHESIOLOGY 116:692-700(2012).
- Maguire, DP; Turton, JA; et al. Correlation of Histopathology, Urinary Biomarkers, and Gene Expression Responses Following Hexachloro-1:3-Butadiene-induced Acute Nephrotoxicity in Male Hanover Wistar Rats: A 28-day Time Course Study. TOXICOLOGIC PATHOLOGY 41:779-794(2013).
