Recombinant Human Heme Oxygenase (decycling) 1, GST-tagged

• Cat.No.: HMOX1-1597H
• Product Overview: Recombinant full-length human HMOX1 was expressed in E. coli cells using an N-terminal GST tag

Specification

• Cat. No.: HMOX1-1597H
• Description: HMOX1 (Heme oxygenase 1) catalyzes the oxidative cleavage of heme to biliverdin and is one of the main genes controlling heme synthesis and catabolism. HMOX1 plays a protective role in various disorders and can ameliorate experimental MN via multiple pathways, including anti-oxidative and immunomodulatory effects.
• Applications: Western Blot
• Molecular Weight: 56 kDa
• Expression System: E. coli
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: >95%
• Concentration: 0.2 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: HIF-1-alpha transcription factor network; Iron uptake and transport; Iron uptake and transport; Keap1-Nrf2 Pathway; Mineral absorption; Mineral absorption; Oxidative Stress; Transmembrane transport of small molecules; Validated transcriptional targets of AP1 family members Fra1 and Fra2; Validated transcriptional targets of AP1 family members Fra1 and Fra2; heme degradation

Gene Information

• Gene Name: HMOX1 heme oxygenase (decycling) 1 [ Homo sapiens ]
• Official Symbol: HMOX1
• Synonyms: HMOX1; heme oxygenase (decycling) 1; HO-1; HSP32; bK286B10; heme oxygenase 1; OTTHUMP00000198812; heat shock protein, 32-kD
• Gene ID: 3162
• mRNA Refseq: NM_002133
• Protein Refseq: NP_002124
• MIM: 141250
• UniProt ID: P09601
• Chromosome Location: 22q12
• Function: enzyme binding; heme binding; heme oxygenase (decyclizing) activity; metal ion binding; oxidoreductase activity; phospholipase D activity; protein homodimerization activity; signal transducer activity