Recombinant Rat Hmox1, His-tagged

• Cat.No.: Hmox1-31R
• Product Overview: Recombinant Rat Hmox1, fused with His tag, was expressed in E. coli.

Specification

• Species: Rat
• Source: E.coli
• Tag: His
• Description: Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin. These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs.There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals.
• Form: 50mM Tris/HCl pH7.5, 5mM Bme, 0.15NaCl, 10% glycerol
• Molecular Mass: ~32kDa
• Purity: >90% pure by SDS - PAGE analysis.
• Storage: -20°C; 1 year+ Avoid freeze/ thaw cycle.

Gene Information

• Gene Name: Hmox1 heme oxygenase (decycling) 1 [ Rattus norvegicus ]
• Official Symbol: Hmox1
• Synonyms: HMOX1; heme oxygenase (decycling) 1; heme oxygenase 1; heme oxygenase (decyclizing) 1; Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32
• Gene ID: 24451
• mRNA Refseq: NM_012580
• Protein Refseq: NP_036712
• Pathway: Heme degradation, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Keap1-Nrf2, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of porphyrins, organism-specific biosystem; Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem
• Function: enzyme binding; heme binding; heme binding; heme oxygenase (decyclizing) activity; heme oxygenase (decyclizing) activity; heme oxygenase (decyclizing) activity; heme oxygenase (decyclizing) activity; metal ion binding; oxidoreductase activity; phospholipase D activity; protein binding; protein homodimerization activity; protein homodimerization activity; signal transducer activity; signal transducer activity