Recombinant Rat Hmox1, His-tagged

• Cat.No.: Hmox1-31R
• Product Overview: Recombinant Rat Hmox1, fused with His tag, was expressed in E. coli.

Specification

• Description: Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin. These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs.There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals.
• Source: E. coli
• Species: Rat
• Tag: His
• Form: 50mM Tris/HCl pH7.5, 5mM Bme, 0.15NaCl, 10% glycerol
• Molecular Mass: ~32kDa
• Purity: >90% pure by SDS - PAGE analysis.
• Storage: -20°C; 1 year+ Avoid freeze/ thaw cycle.

Gene Information

• Gene Name: Hmox1 heme oxygenase (decycling) 1 [ Rattus norvegicus ]
• Official Symbol: Hmox1
• Synonyms: HMOX1; heme oxygenase (decycling) 1; heme oxygenase 1; heme oxygenase (decyclizing) 1; Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32
• Gene ID: 24451
• mRNA Refseq: NM_012580
• Protein Refseq: NP_036712
• Pathway: Heme degradation, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Keap1-Nrf2, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of porphyrins, organism-specific biosystem; Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem
• Function: enzyme binding; heme binding; heme binding; heme oxygenase (decyclizing) activity; heme oxygenase (decyclizing) activity; heme oxygenase (decyclizing) activity; heme oxygenase (decyclizing) activity; metal ion binding; oxidoreductase activity; phospholipase D activity; protein binding; protein homodimerization activity; protein homodimerization activity; signal transducer activity; signal transducer activity

Reviews

10/03/2021

A reliable source for top-notch proteins. Fast shipping is a big plus.

04/14/2020

Exceptional service! This product has become a staple in our lab.

09/30/2018

Impressed with the product's quality. Shipping is always on time.

Q&As

Can you discuss the role of HMOX1 in modulating the immune response in the context of infectious diseases, and how its induction may impact host-pathogen interactions?

HMOX1 modulates the immune response during infectious diseases, influencing host-pathogen interactions. Its induction can contribute to an anti-inflammatory environment and impact the outcome of infections.

How does HMOX1 contribute to the regulation of iron homeostasis, and what are the molecular mechanisms involved in its interaction with iron-responsive elements?

HMOX1 regulates iron homeostasis by releasing free iron during heme degradation. Its interaction with iron-responsive elements influences cellular iron levels and responses to iron availability.

What is the relationship between HMOX1 and oxidative stress-induced autophagy, and how does this connection influence cellular responses to stressors?

HMOX1 is linked to oxidative stress-induced autophagy, contributing to cellular adaptation and survival. This connection influences the cellular response to stressors by promoting self-cleaning mechanisms.

Can you discuss the role of HMOX1 in vascular health and its impact on endothelial function, particularly in the context of cardiovascular diseases?

HMOX1 plays a role in vascular health by protecting endothelial cells. Its anti-inflammatory and vasodilatory effects contribute to cardiovascular protection and may have implications for disease prevention.

How does HMOX1 participate in the modulation of the immune response, and what are the mechanisms by which it influences inflammatory pathways?

HMOX1 modulates the immune response by suppressing inflammation. It inhibits pro-inflammatory pathways by influencing transcription factors and inhibiting the production of inflammatory mediators.