Recombinant Human HAX1, GST-tagged

• Cat.No.: HAX1-13677H
• Product Overview: Recombinant Human HAX1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-279a.a.
• Description: The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HAX1 HCLS1 associated protein X-1 [ Homo sapiens ]
• Official Symbol: HAX1
• Synonyms: HAX1; HCLS1 associated protein X-1; HCLS1-associated protein X-1; HCLS1 (and PKD2) associated protein; HCLSBP1; HS1BP1; HAX-1; HSP1BP-1; HS1 binding protein; HS1-binding protein 1; HS1-associating protein X-1; SCN3; FLJ17042; FLJ18492; FLJ93803
• Gene ID: 10456
• mRNA Refseq: NM_001018837
• Protein Refseq: NP_001018238
• MIM: 605998
• UniProt ID: O00165
• Chromosome Location: 1q21.3
• Function: interleukin-1 binding; protein N-terminus binding; protein binding