Recombinant Human HAP1 protein, His & GST-tagged

• Cat.No.: HAP1-1598H
• Product Overview: Recombinant Human HAP1 aa. (Pro160~Gln381 (Accession # P54257)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: Pro160~Gln381
• Description: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 55.9kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 4.2

Gene Information

• Gene Name: HAP1 huntingtin associated protein 1 [ Homo sapiens (human) ]
• Official Symbol: HAP1
• Synonyms: HAP1; huntingtin associated protein 1; HLP; HAP2; HIP5; hHLP1; huntingtin-associated protein 1; HAP-1; huntingtin-associated protein 2; neuroan 1
• Gene ID: 9001
• mRNA Refseq: NM_001079870.1
• Protein Refseq: NP_001073339.1
• UniProt ID: P54257