Recombinant Human H2AFY Protein, HIS-tagged

• Cat.No.: H2AFY-133H
• Product Overview: Recombinant Human H2AFY, transcript variant 4, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Form: 50mM Tris, 8M Urea, pH8.0.
• Molecular Mass: 39.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: H2AFY H2A histone family, member Y [ Homo sapiens ]
• Official Symbol: H2AFY
• Synonyms: H2AFY; H2A histone family, member Y; core histone macro-H2A.1; macroH2A1.2; histone H2A.y; histone macroH2A1; histone macroH2A1.1; histone macroH2A1.2; medulloblastoma antigen MU-MB-50.205; H2A.y; H2A/y; H2AFJ; mH2A1; H2AF12M; MACROH2A1.1
• Gene ID: 9555
• mRNA Refseq: NM_001040158
• Protein Refseq: NP_001035248
• MIM: 610054
• UniProt ID: O75367