Recombinant Human H2AFX Protein (Met1-Tyr143), His tagged

• Cat.No.: H2AFX-3068H
• Product Overview: Recombinant human H2AFX (Met1-Tyr143) protein fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: Met1-Tyr143
• Description: H2AFX variants are associated with an increased risk of breast cancer (BC). H2AFX gene encodes a member of the H2A histone family which is central in the detection of and response to DNA double-strand breaks. In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage response. Due to the critical role of the H2AX histone variant in double-strand break repair, genetic variants in the H2AX gene, H2AFX, may influence cancer susceptibility. H2AFX encodes a histone variant involved in signaling sites of DNA damage and recruiting repair factors. Genetic variants in H2AFX may influence risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of lymphoid tumors that are characterized by chromosomal translocations.
• Molecular Mass: 16.64 kDa
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: H2AFX H2A histone family, member X [ Homo sapiens (human) ]
• Official Symbol: H2AFX
• Synonyms: H2AFX; H2A histone family, member X; H2AX; histone H2A.x; H2AX histone; H2A.X; H2A/X
• Gene ID: 3014
• mRNA Refseq: NM_002105
• Protein Refseq: NP_002096
• MIM: 601772
• UniProt ID: P16104