H2AFX
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Official Full Name
H2A histone family, member X -
Overview
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008] -
Synonyms
H2AFX;H2A histone family, member X;H2AX;H2A.X;H2A/X;histone H2AX;H2AX histone;histone H2A.x
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
H2AFX involved in several pathways and played different roles in them. We selected most pathways H2AFX participated on our site, such as Alcoholism,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H2AFX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | C4A,HIST1H2BQ,CD40LG,HIST1H2AK,HIST2H4A,HIST1H2AC,C1S,C1QC,HIST3H3,ELANE |
| Alcoholism | GRB2,HIST1H2AP,HIST1H3F,GNG4,HIST1H2BP,HIST1H2AO,GM14479,CREB5,PPP1CA,ADORA2A |
Protein Function
H2AFX has several biochemical functions, for example, DNA binding,damaged DNA binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by H2AFX itself. We selected most functions H2AFX had, and list some proteins which have the same functions with H2AFX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | MEF2AA,FOXN4,DNTTIP1,ZNF454,LTF,ZFP516,FOXB1B,POGZ,SCRT2,SOX19A |
| enzyme binding | TMBIM6,SLC27A2,PIAS1,EIF4E,VAPB,CBS,PTPN1,UGT1A6B,RCOR3,TRAF2 |
| histone binding | CTCFL,HIST1H4A,IPO7,HIST1H4L,CTSL2,NASP,HINFP,NFKBIL2,HIST1H3D,PRMT6 |
| damaged DNA binding | CRY2,REV1,HMGB2,GTF2H3,XRCC6,TP63,RAD23B,POLD1,XPC,TP73 |
| protein heterodimerization activity | IKBKG,H2AFY,TYRO3,IKZF1,OSTA,CLCN3,APITD1,HSPD1,HIST1H2B8,DDX1 |
| protein binding | GRAP2,AHR,GP6,CCKBR,CD3E,STK24,ZNF32,TOMM34,NEK8,PFDN4 |
Interacting Protein
H2AFX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H2AFX here. Most of them are supplied by our site. Hope this information will be useful for your research of H2AFX.
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