Recombinant Human GZMB

• Cat.No.: GZMB-757H
• Product Overview: Recombinant human granzyme B was expressed inE. coli.MW = 25511 Da.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Granzyme B (GzmB) is a serine protease that is involved in cytotoxic T lymphocyte-induced (CTL) cell death. It is reported to participate in the perforation of target cells and initiation of protelolysis that leads apoptosis. Similar to caspases, granzyme B preferentially cleaves substrate proteins with aspartic acid in the P1 position.
• Form: Liquid. In TBS, 50% glycerol.
• Specific Activity: ≥7.0 units/µg protein.
• Unit Definition: One unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-pNA per min 25℃, pH 8.0.
• Toxicity: Standard Handling (MSDS available upon request).
• Storage: ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃).

Gene Information

• Gene Name: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [ Homo sapiens ]
• Synonyms: GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; granzyme B; fragmentin 2; cathepsin G-like 1; T-cell serine protease 1-3E; cytotoxic serine protease B; EC 3.4.21.79; Granzyme-2; Cytotoxic T-lymphocyte proteinase 2; Human lymphocyte protein; Lymphocyte protease; C11; Fragmentin-2; GRB
• Gene ID: 3002
• mRNA Refseq: NM_004131
• Protein Refseq: NP_004122
• MIM: 123910
• UniProt ID: P10144
• Chromosome Location: 14q11.2
• Pathway: Allograft rejection; Autoimmune thyroid disease; Graft-versus-host disease; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus
• Function: peptidase activity; protein binding; serine-type endopeptidase activity