Recombinant Human GTF2B, GST-tagged
Cat.No. : | GTF2B-13590H |
Product Overview : | Recombinant Human GTF2B protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
Availability | March 13, 2025 |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Protein Length : | 1-316a.a. |
Description : | Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name | GTF2B general transcription factor IIB [ Homo sapiens ] |
Official Symbol | GTF2B |
Synonyms | GTF2B; general transcription factor IIB; transcription initiation factor IIB; TFIIB; S300-II; general transcription factor TFIIB; RNA polymerase II transcription factor IIB; TF2B; |
Gene ID | 2959 |
mRNA Refseq | NM_001514 |
Protein Refseq | NP_001505 |
MIM | 189963 |
UniProt ID | Q00403 |
Chromosome Location | 1p22-p21 |
Pathway | Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Disease, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem; |
Function | DNA binding; metal ion binding; protein binding; thyroid hormone receptor binding; transcription factor binding; translation initiation factor activity; zinc ion binding; |
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◆ Cell & Tissue Lysates | ||
GTF2B-5703HCL | Recombinant Human GTF2B 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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