Recombinant Human Growth Differentiation Factor 7

• Cat.No.: GDF7-39H
• Product Overview: Recombinant human GDF7 is a 27 kDa disulfide-linked homodimer containing two 122 amino acid polypeptide chains.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: GDF7 belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, GDF7 promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. GDF7 is highly conserved across species. GDF7 regulates chondrogenesis, bone morphogenesis, and neuron differentiation.
• Biological Activity: The protein is biologically active as determined by its ability to induce alkaline phosphatase production by ADTC5 mouse chondrogenic cells. The ED₅₀ for this effect is typically 0.2-2.5 µg/ml.
• Molecular Weight: 27 kDa
• Form: Lyophilized without additives.
• Endotoxin Level: < 0.1 ng/μg
• Appearance: Lyophilized protein
• Purity: ≥ 98% by SDS-PAGE and ≥ 98 % by HPLC
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute to a concentration of 0.1-1.0 mg/ml in water containing BSA (50 ug BSA per 1 ug of protein). This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
• Storage: The lyophilized protein is best-stored desiccated below 0°C. Reconstituted BMP-5 should be stored in working aliquots at -20°C.

Gene Information

• Gene Name: GDF7 growth differentiation factor 7 [ Homo sapiens ]
• Official Symbol: GDF7
• Synonyms: GDF7; growth differentiation factor 7; BMP12; GDF-7; growth differentiation factor 7; growth/differentiation factor 7; OTTHUMP00000115986
• Gene ID: 151449
• mRNA Refseq: NM_182828
• Protein Refseq: NP_878248
• MIM: 604651
• UniProt ID: Q7Z4P5
• Chromosome Location: 2p24.1
• Pathway: TGF-beta signaling pathway
• Function: cytokine activity; growth factor activity; protein binding; protein homodimerization activity