Recombinant Human GRM1 protein, His & T7-tagged

• Cat.No.: GRM1-1355H
• Product Overview: Recombinant Human GRM1 aa. (Ser165~Glu592 (Accession# Q13255) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Ser165~Glu592
• Description: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 52.3kDa
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.4.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: GRM1 glutamate metabotropic receptor 1 [ Homo sapiens (human) ]
• Official Symbol: GRM1
• Synonyms: GRM1; glutamate metabotropic receptor 1; MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85; metabotropic glutamate receptor 1; glutamate receptor, metabotropic 1; protein phosphatase 1, regulatory subunit 85
• Gene ID: 2911
• mRNA Refseq: NM_001278064.1
• Protein Refseq: NP_001264993.1
• UniProt ID: Q13255