Recombinant Human GRB2 Protein, DYKDDDDK-tagged

• Cat.No.: GRB2-151H
• Product Overview: Recombinant Human growth factor receptor bound protein 2(GRB2), transcript variant 1(NM_002086), with a DYKDDDDK tag, was expressed in human cells.

Specification

• Species: Human
• Source: Human Cells
• Tag: Flag
• Description: Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
• Form: Purified protein formulated in a sterile solution of TBS buffer, pH7.339, without any preservatives.
• Molecular Mass: 25 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.

Gene Information

• Gene Name: GRB2 growth factor receptor-bound protein 2 [ Homo sapiens ]
• Official Symbol: GRB2
• Synonyms: GRB2; growth factor receptor-bound protein 2; NCKAP2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2; ASH; Grb3-3; MST084; MSTP084; EGFRBP-GRB2
• Gene ID: 2885
• mRNA Refseq: NM_002086
• Protein Refseq: NP_002077
• MIM: 108355
• UniProt ID: P62993