Recombinant Human GRAM Domain Containing 3, His-tagged

• Cat.No.: GRAMD3-2175H
• Product Overview: Recombinant Human GRAM Domain Containing 3 is produced inE. coliandfused at the N-terminus to a His-tag. MW= 69 kDa.

Specification

• Cat. No.: GRAMD3-2175H
• Description: An evaluation of the RPE signature genes in a recently completed AMD genomewide association (GWA) data set revealed that TIMP3, GRAMD3, PITPNA and CHRNA3 signature genes may have potential roles in AMD pathogenesis and deserve further examination. We propose that RPE signature genes are excellent candidates for retinal diseases and for physiological investigations (e.g. dopachrome tautomerase in melanogenesis). The RPE signature gene set should allow the validation of RPE-like cells derived from human embryonic or induced pluripotent stem cells for cell-based therapies of degenerative retinal diseases.
• Source: E. coli.
• Concentration: 379ng/μl (5µM).
• Purity: ≥85% (SDS-PAGE).
• Formulation: Liquid. In 25mM HEPES, pH 7.6, containing 1mM EDTA, 3mM DTT, 0.5M sodium chloride, 0.2% Triton X-100 and 20% glycerol.
• Biological Activity: IC50 (lot-specific).
• Application: Suitable for screenings.
• Storage And Stability: -80°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: GRAMD3 GRAM domain containing 3 [ Homo sapiens ]
• Synonyms: GRAMD3; GRAM domain containing 3; NS3TP2; FLJ21313; GRAM domain-containing protein 3; HCV NS3-transactivated protein 2; hepatitis C virus nonstructural protein 3-transactivating protein 2
• Gene ID: 65983
• mRNA Refseq: NM_001146319
• Protein Refseq: NP_001139791
• UniProt ID: Q96HH9
• Chromosome Location: 5q23.2