Recombinant Human GPN-Loop GTPase 1, His-tagged

• Cat.No.: GPN1-6847H
• Product Overview: Recombinant human GPN1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-374aa
• Description: GPN1 belongs to the GPN-loop GTPase family. Small GTPases share a biochemical mechanism and act as binary molecular switches. One important function of small GTPases in the cell is nucleocytoplasmic transport of both proteins and RNA. This protein may play a role in DNA repair and may function in activation of transcription.
• Form: Liquid. In 20 mM Tris-HCl buffer, pH8.0, 10% glycerol, 1mM DTT, 50mM NaCl.
• Molecular Mass: 44.3kDa (398aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAASAA AAELQASGGP RHPVCLLVLG MAGSGKTTFV QRLTGHLHAQ GTPPYVINLD PAVHEVPFPA NIDIRDTVKY KEVMKQYGLG PNGGIVTSLN LFATRFDQVM KFIEKAQNMS KYVLIDTPGQ IEVFTWSASG TIITEALASS FPTVVIYVMD TSRSTNPVTF MSNMLYACSI LYKTKLPFIV VMNKTDIIDH SFAVEWMQDF EAFQDALNQE TTYVSNLTRS MSLVLDEFYS SLRVVGVSAV LGTGLDELFV QVTSAAEEYE REYRPEYERL KKSLANAESQ QQREQLERLR KDMGSVALDA GTAKDSLSPV LHPSDLILTR GTLDEEDEEA DSDTDDIDHR VTEESHEEPA FQNFMQESMA QYWKRNNK
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: GPN1 GPN-loop GTPase 1 [ Homo sapiens ]
• Official Symbol: GPN1
• Synonyms: GPN1; GPN-loop GTPase 1; XAB1, XPA binding protein 1 , XPA binding protein 1, GTPase; ATPBD1A; MBDIN; NTPBP; RNA polymerase II associated protein 4; RPAP4; XPA-binding protein 1; ATP(GTP)-binding protein; MBD2-interacting protein; XPA binding protein 1, GTPase; XAB1; FLJ51176
• Gene ID: 11321
• mRNA Refseq: NM_001145047
• Protein Refseq: NP_001138519
• MIM: 611479
• UniProt ID: Q9HCN4
• Chromosome Location: 2p23.3
• Function: GTP binding; nucleoside-triphosphatase activity; nucleotide binding