Recombinant Human GPHN, GST-tagged

• Cat.No.: GPHN-13423H
• Product Overview: Recombinant Human GPHN protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: N-term-315a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GPHN gephyrin [ Homo sapiens ]
• Official Symbol: GPHN
• Synonyms: GPHN; gephyrin; KIAA1385; GPH; GEPH; GPHRYN
• Gene ID: 10243
• mRNA Refseq: NM_001024218
• Protein Refseq: NP_001019389
• MIM: 603930
• UniProt ID: Q9NQX3
• Chromosome Location: 14q23.3
• Pathway: GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Molybdenum cofactor biosynthesis, organism-specific biosystem; molybdenum cofactor biosynthesis, conserved biosystem
• Function: ATP binding; metal ion binding; nucleotide binding; transferase activity