GPHN
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Official Full Name
gephyrin -
Overview
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. -
Synonyms
GPHN;gephyrin;KIAA1385;Domain E;Domain G;GEPH;GEPH_HUMAN;GPH;GPHRYN;Molybdopterin molybdenumtransferase;MPT adenylyltransferase;MPT Mo-transferase
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
GPHN involved in several pathways and played different roles in them. We selected most pathways GPHN participated on our site, such as GABAergic synapse,Metabolism,Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPHN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | ISCUB,CYP27A1,PPM1LA,ETFB,ARSE,TACO1,ARV1,AKR1C21,AK7A,NUDT4B |
| Metabolism of vitamins and cofactors | SLC25A32A,KCNG4,CBLC-1,ELA2,ELA2L,SLC23A2,PDZD11,SLC25A16,SLC52A3,SLC25A32B |
| Metabolism of water-soluble vitamins and cofactors | SLC46A1,SLC23A2,MOCOS,CYB5R3,ELA2,CYB5A,GSTO2,SLC5A6B,SLC19A2,CBLC-1 |
| Molybdenum cofactor biosynthesis | MOCOS,GPHNA |
| GABAergic synapse | GNAI2,GLUL,SLC12A5,GABRR3,GABARAPL2,GNG12,SLC38A3,GABRE,GLS,SLC38A5 |
Protein Function
GPHN has several biochemical functions, for example, ATP binding,metal ion binding,molybdopterin adenylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPHN itself. We selected most functions GPHN had, and list some proteins which have the same functions with GPHN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molybdopterin adenylyltransferase activity | GPHNB |
| molybdopterin molybdotransferase activity | GPHNB |
| metal ion binding | CYP19A1B,ADK,ZNF223,ZFP57,ZNF165,PRDM6,JADE3,CNOT6L,JAZF1A,C6AST4 |
| ATP binding | DDX53,MATK,CKM,ERN2,OXSR1B,TTLL5,SIK2A,RFC4,MAPK14,PSKH1 |
Interacting Protein
GPHN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPHN here. Most of them are supplied by our site. Hope this information will be useful for your research of GPHN.
DYNLL1;PRPF4;Dynll1;OTUD4;ACADVL;KHDRBS1;SPATS1;SLX4;CDCA5
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References
- Petit-Pedrol, M; Armangue, T; et al. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABA(A) receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. LANCET NEUROLOGY 13:276-286(2014).
- Notter, T; Panzanelli, P; et al. A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system. EUROPEAN JOURNAL OF NEUROSCIENCE 39:165-175(2014).
