Recombinant Human GNG4, His-tagged

• Cat.No.: GNG4-5023H
• Product Overview: Recombinant human GNG4 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor, also known as GNG4, is members of a multigene family and are implicated in determining the specificity of receptor-G protein interaction. In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. GNG4 is becoming increasingly clear that different G protein complexes expressed in different tissues carry structurally distinct members of the gamma as well as the alpha and beta subunits and that preferential association between members of subunit families increase G protein functional diversity.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 10.4 kDa (95aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMKEGMSN NSTTSISQAR KAVEQLKMEA CMDRVKVSQA AADLLAYCEA HVREDPLIIP VPASENPFRE KKFFC
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: GNG4 guanine nucleotide binding protein (G protein), gamma 4 [ Homo sapiens ]
• Official Symbol: GNG4
• Synonyms: GNG4; guanine nucleotide binding protein (G protein), gamma 4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; guanine nucleotide binding protein 4; FLJ23803; FLJ34187; DKFZp547K1018
• Gene ID: 2786
• mRNA Refseq: NM_001098721
• Protein Refseq: NP_001092191
• MIM: 604388
• UniProt ID: P50150
• Chromosome Location: 1q42.3
• Pathway: ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; ADP signalling through P2Y purinoceptor 12, organism-specific biosystem; Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Aquaporin-mediated transport, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem
• Function: signal transducer activity