Recombinant Human GMNN Protein (M1-I209), His/Strep tagged

• Cat.No.: GMNN-0566H
• Product Overview: Recombinant Human 6His-strepII-TEV-GG-GMNN(M1-I209 end) Protein was expressed in E. coli.

Specification

• Description: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
• Source: E. coli
• Species: Human
• Tag: His&Strep
• Form: Liquid
• Protein length: M1-I209
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: GMNN geminin, DNA replication inhibitor [ Homo sapiens (human) ]
• Official Symbol: GMNN
• Synonyms: GMNN; geminin, DNA replication inhibitor; geminin; Gem
• Gene ID: 51053
• mRNA Refseq: NM_001251989
• Protein Refseq: NP_001238918
• MIM: 602842
• UniProt ID: O75496