Recombinant Human Geminin, DNA Replication Inhibitor, His-tagged

• Cat.No.: GMNN-353H
• Product Overview: Recombinant human GMNN protein expressed in E.coli, 27.6kDa (245aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Recombinant human, Geminin is a 25 kDa protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. In addition, geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 5 mM DTT, 20% glycerol.
• Purity: > 95% by SDS - PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNPS MKQK QE EIK E NIKNSSVPRR TLKMIQPSAS GSLVGRENEL SAGLSKRKHR NDHLTS T TSS PGVIVPESSE NKNLGGVTQE SFDLMIKENP SSQYWKEVAE KRRKALY EAL KENEKLHKEI EQKDNEIARL KKENKELAEV AEHVQYMAEL IERLNGEP LD NFESLDNQEF DSEEETVEDS LVEDSEIGTC AEGTVSSSTD AKPCI
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GMNN geminin, DNA replication inhibitor [ Homo sapiens ]
• Synonyms: GMNN; Gem; RP3-369A17.3; geminin; OTTHUMP00000039393; geminin, DNA replication inhibitor.
• Gene ID: 51053
• mRNA Refseq: NM_015895
• Protein Refseq: NP_056979
• MIM: 602842
• UniProt ID: O75496
• Chromosome Location: 6p22.3
• Function: protein binding