Recombinant Human Glia Maturation Factor, Beta, His-tagged

• Cat.No.: GMFB-2794H
• Product Overview: Recombinant human GMFB protein (1-142 aa), fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-142 a.a.
• Description: GMFB, also known as GMF, belongs to the GMF subfamily of the larger actin-binding protein ADF family. This protein, which is phosphorylated following phorbol ester stimulation, is important for the nervous system. It causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. Overexpression of GMFB in astrocytes has been shown to enhance brain-derived neurotrohic factor (BDNF) production. GMFB expression is increased by exercise, and the protein is crucial for exercise-induction of BDNF.
• Sequences: MGSSHHHHHH SSGLVPRGSH MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M Nacl, 1mM DTT, 10% glycerol.
• Molecular Weight: 18.8 kDa (162aa),confirmed by MALDI-TOF.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GMFB glia maturation factor, beta [ Homo sapiens ]
• Synonyms:
  GMFB; glia maturation factor, beta; GMF-beta; glia maturation factor beta; GMF
• Gene ID: 2764
• mRNA Refseq: NM_004124
• Protein Refseq: NP_004115
• MIM: 601713
• UniProt ID: P60983
• Chromosome Location: 14q22.2
• Function: actin binding; enzyme activator activity; growth factor activity; protein kinase inhibitor activity; signal transducer activity