Recombinant Human GLDC, His-tagged

• Cat.No.: GLDC-13294H
• Product Overview: Recombinant Human GLDC protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 675-1020a.a.
• Description: The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GLDC glycine dehydrogenase (decarboxylating) [ Homo sapiens ]
• Official Symbol: GLDC
• Synonyms: GLDC; glycine dehydrogenase (decarboxylating); glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P); glycine dehydrogenase [decarboxylating], mitochondrial; GCSP; glycine cleavage system protein P; glycine decarboxylase; NKH; glycine decarboxylase P-protein; glycine cleavage system P protein; GCE; HYGN1; MGC138198; MGC138200
• Gene ID: 2731
• mRNA Refseq: NM_000170
• Protein Refseq: NP_000161
• MIM: 238300
• UniProt ID: P23378
• Chromosome Location: 9p22
• Pathway: Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; glycine cleavage complex, organism-specific biosystem
• Function: electron carrier activity; glycine dehydrogenase (decarboxylating) activity; lyase activity; oxidoreductase activity; pyridoxal phosphate binding