Recombinant Human GGCT, His-tagged

• Cat.No.: GGCT-28745TH
• Product Overview: Recombinant full length Human GGCT with an N terminal His tag; 208 amino acids with tag, Predicted MWt 23.2 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 188 amino acids
• Description: The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Conjugation: HIS
• Molecular Weight: 23.200kDa inclusive of tags
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL

Gene Information

• Gene Name: GGCT gamma-glutamylcyclotransferase [ Homo sapiens ]
• Official Symbol: GGCT
• Synonyms: GGCT; gamma-glutamylcyclotransferase; C7orf24, chromosome 7 open reading frame 24 , GCTG; CRF21; Ggc; MGC3077
• Gene ID: 79017
• mRNA Refseq: NM_001199817
• Protein Refseq: NP_001186746
• MIM: 137170
• Uniprot ID: O75223
• Chromosome Location: 7p15-p14
• Pathway: Biological oxidations, organism-specific biosystem; Glutathione conjugation, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Glutathione synthesis and recycling, organism-specific biosystem
• Function: gamma-glutamylcyclotransferase activity; gamma-glutamylcyclotransferase activity; protein homodimerization activity; transferase activity, transferring acyl groups