GGCT
-
Official Full Name
gamma-glutamylcyclotransferase -
Overview
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
GGCT;gamma-glutamylcyclotransferase;C7orf24, chromosome 7 open reading frame 24 , GCTG;CRF21;Ggc;MGC3077;cytochrome c-releasing factor 21;gamma -glutamyl cyclotransferase;GCTG;C7orf24;FLJ11717
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GGCT-13239H | Recombinant Human GGCT, His-tagged | E.coli | Human | His | 1-188a.a. | |
| GGCT-1030H |
Active Recombinant Human GGCT
|
E.coli | Human | Non | Met1-Leu188 |
|
| GGCT-1837R | Recombinant Rhesus monkey GGCT Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
|
|
| GGCT-28745TH | Recombinant Human GGCT, His-tagged | E.coli | Human | His | 188 amino acids |
|
| GGCT-307H | Recombinant Human GGCT Protein, His-tagged | E.coli | Human | His | 1-188 a.a. |
|
| GGCT-538H | Recombinant Human GGCT protein, His-tagged | E.coli | Human | His | Met1-Leu188 |
|
| GGCT-956H | Recombinant Human GGCT, His-tagged | E.coli | Human | His |
|
|
| GGCT-1658R | Recombinant Rhesus Macaque GGCT Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
|
| GGCT-1658R-B | Recombinant Rhesus Macaque GGCT Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
||
| GGCT-2956H | Recombinant Human GGCT protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-188aa |
|
| Ggct-457M | Recombinant Mouse Ggct Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
|
| GGCT-4869H | Recombinant Human GGCT Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| GGCT-5455HF | Recombinant Full Length Human GGCT Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 188 amino acids |
|
| GGCT-5520H | Recombinant Human GGCT Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
|
| GGCT-7474H | Recombinant Human GGCT protein, His-tagged | E.coli | Human | His | 203aa(including fusion tag) |
|
Involved Pathway
GGCT involved in several pathways and played different roles in them. We selected most pathways GGCT participated on our site, such as Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGCT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | GPX5,G6PD,RRM1,MGST3,GCLM,TXNDC12,GSS,ANPEP,SRM,GGCTB |
Protein Function
GGCT has several biochemical functions, for example, gamma-glutamylcyclotransferase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGCT itself. We selected most functions GGCT had, and list some proteins which have the same functions with GGCT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| gamma-glutamylcyclotransferase activity | GGCTA,GGACT,GGCTB,GGACT.1,GGACT.2,GGACT.3 |
| protein homodimerization activity | CD226,PTS,CD4,DPP4,CREB3,CDSN,GNB2L1,CRTAM,SRGAP2,ATPIF1A |
Interacting Protein
GGCT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGCT here. Most of them are supplied by our site. Hope this information will be useful for your research of GGCT.
RASSF10;RASSF9;EGFR;RASSF7;STK4;TSNAX
Resources
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References
- Ran, R; Liu, YY; et al. PEGylated Hyaluronic Acid-Modified Liposomal Delivery System with Anti-gamma-Glutamylcyclotransferase siRNA for Drug-Resistant MCF-7 Breast Cancer Therapy. JOURNAL OF PHARMACEUTICAL SCIENCES 104:476-484(2015).
- Yoshiya, T; Ii, H; et al. A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells. ORGANIC & BIOMOLECULAR CHEMISTRY 13:3182-3185(2015).
