Recombinant Human GGCT, His-tagged

• Cat.No.: GGCT-956H
• Product Overview: Recombinant human GGCT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: GGCT, also known as gamma-glutamylcyclotransferase, belongs to the family of transferases, specifically the aminoacyltransferases. This protein catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. GGCT induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
• Molecular Weight: 23.2 kDa (208aa) confirmed by MALDI-TOF.
• Purity: > 95% by SDS - PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MANSGCKDVT GPDEESFLYF AYGSNLLTER IHLRNPSAAF FCVARLQDFK LDFGNSQGKT SQTWHGGIAT IFQSPGDEVW GVVWKMNKSN LNSLDEQEGV KSGMYVVIEV KVATQEGKEI TCRSYLMTNY ESAPPSPQYK KIICMGAKEN GLPLEYQEKL KAIEPNDYTG KVSEEIEDII KKGETQTL.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Glutathione metabolism

Gene Information

• Gene Name: GGCT gamma-glutamylcyclotransferase [ Homo sapiens ]
• Synonyms: gamma-glutamylcyclotransferase;gam-ma-glutamyl cyclotransferase; GGC; GCTG; CRF21; C7orf24; MGC3077; FLJ11717; GGCT; OTTHUMP000002-02475; cytochrome c-releasing factor 21;Cytochrome c-releasing factor 21; EC 2.3.2.4
• Gene ID: 79017
• mRNA Refseq: NM_024051
• Protein Refseq: NP_076956
• MIM: 137170
• UniProt ID: O75223
• Chromosome Location: 7p15-p14
• Function: acyltransferase activity; gamma-glutamylcyclotransferase activity; protein homodimerization activity; transferase activity