Recombinant Human Germ Cell Associated 2 (haspin), GST-tagged

• Cat.No.: GSG2-1586H
• Product Overview: Recombinant human GSG2 (470-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 470-end a.a.
• Description: GSG2 is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. GSG2 expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. GSG2 phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion ofGSG2 by RNA interference reveals that GSG2 is required for H3 thr3 phosphorylation in mitotic cells.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 64 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: >75%
• Concentration: 0.1 ug/ul
• Specific Activity: 18 nmol/min/mg
• Sequences: 470-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: GSG2 germ cell associated 2 (haspin) [ Homo sapiens ]
• Official Symbol: GSG2
• Synonyms: GSG2; germ cell associated 2 (haspin); HASPIN; serine/threonine-protein kinase haspin; H-haspin; OTTHUMP00000115873; germ cell-specific gene 2 protein; haploid germ cell-specific nuclear protein kinase
• Gene ID: 83903
• mRNA Refseq: NM_031965
• Protein Refseq: NP_114171
• MIM: 609240
• UniProt ID: Q8TF76
• Chromosome Location: 17p13
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity