Recombinant Human Geranylgeranyl Diphosphate Synthase 1, His-tagged

• Cat.No.: GGPS1-2800H
• Product Overview: Recombinant human GGPS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 37 kDa (320aa), confirmed by MALDI-TOF.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Geranylgeranyl pyrophosphate synthase isoform A, also known as GGPS1, is a member of the prenyltransferase family. Predominantly expressed in testis, heart and skeletal muscle, GGPS1 localizes to the cytoplasm and catalyzes the formation of geranylgeranyl pyrophosphate, a precursor of geranylgeranylated proteins and carotenoids. GGPS1 is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor.
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE
• Purity: > 90% by SDS – PAGE.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
• Concentration: 1mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GGPS1 geranylgeranyl diphosphate synthase 1 [ Homo sapiens ]
• Synonyms: GGPS1; geranylgeranyl diphosphate synthase 1; GGPPS; GGPPS1; geranylgeranyl pyrophosphate synthase; GGPPSase; GGPP synthase; OTTHUMP00000216161; OTTHUMP00000216162; OTTHUMP00000216163; OTTHUMP00000216164; EC 2.5.1.1; EC 2.5.1.10; EC 2.5.1.29; Dimethylallyltranstransferase; Geranyltranstransferase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase
• Gene ID: 9453
• mRNA Refseq: NM_001037277
• Protein Refseq: NP_001032354
• MIM: 606982
• UniProt ID: O95749
• Chromosome Location: 1q43
• Pathway: Metabolic pathways; Terpenoid backbone biosynthesis
• Function: dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; transferase activity