Recombinant Human General Transcription Factor IIA, 2, 12kDa, T7-tagged

• Cat.No.: GTF2A2-3000H
• Product Overview: Recombinant Human GTF2A2 protein was expressed in E.coli with T7-tag at the N-terminus. The molecular weight is 12457 Da (109 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Description: General transcription factor IIA, 2, 12kDa is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. GTF2A2 is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFIIB, TFIIE, TFIIF, and TFIIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.
• Sequences of amino acids: 1-109 aa
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3.
• Purity: 95%

Gene Information

• Gene Name: GTF2A2 general transcription factor IIA, 2, 12kDa [ Homo sapiens ]
• Synonyms: TF2A2; TFIIA; HsT18745; GTF2A2; transcription initiation factor IIA subunit 2; TFIIAS; TFIIA-12; TFIIA-gamma; TFIIA p12 subunit; OTTHUMP00000196512; general transcription factor IIA subunit 2; transcription initiation factor IIA gamma chain
• Gene ID: 2958
• mRNA Refseq: NM_004492
• Protein Refseq: NP_004483
• MIM: 600519
• UniProt ID: P52657
• Chromosome Location: 15q22.2
• Pathway: Basal transcription factors; Gene Expression; HIV Infection; Transcription
• Function: RNA polymerase II transcription factor activity; TATA-binding protein binding; general RNA polymerase II transcription factor activity; contributes_to general RNA polymerase II transcription factor activity; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription coactivator activity; transcription factor binding