Recombinant Human GEMIN2 Protein, MYC/DDK-tagged

• Cat.No.: GEMIN2-627H
• Product Overview: Recombinant Human GEMIN2, transcript variant alpha, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 31.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GEMIN2 gem (nuclear organelle) associated protein 2 [ Homo sapiens ]
• Official Symbol: GEMIN2
• Synonyms: GEMIN2; gem (nuclear organelle) associated protein 2; SIP1, survival of motor neuron protein interacting protein 1; gem-associated protein 2; gemin-2; component of gems 2; SMN interacting protein 1-delta; survival of motor neuron protein interacting protein 1; SIP1; SIP1-delta
• Gene ID: 8487
• mRNA Refseq: NM_003616
• Protein Refseq: NP_003607
• MIM: 602595
• UniProt ID: O14893