Recombinant Human GCLC
Cat.No. : | GCLC-28159TH |
Product Overview : | Recombinant full length Human GCLC with a proprietary tag; Predicted MWt 96.14. |
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Species : | Human |
Source : | Wheat Germ |
Tag : | Non |
Protein Length : | 637 amino acids |
Description : | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. |
Molecular Weight : | 96.140kDa inclusive of tags |
Biological activity : | useful for Antibody Production and Protein Array |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the glutamate--cysteine ligase type 3 family. |
Gene Name | GCLC glutamate-cysteine ligase, catalytic subunit [ Homo sapiens ] |
Official Symbol | GCLC |
Synonyms | GCLC; glutamate-cysteine ligase, catalytic subunit; GLCL, GLCLC; glutamate--cysteine ligase catalytic subunit; GCS; |
Gene ID | 2729 |
mRNA Refseq | NM_001197115 |
Protein Refseq | NP_001184044 |
MIM | 606857 |
Uniprot ID | P48506 |
Chromosome Location | 6p12 |
Pathway | Biological oxidations, organism-specific biosystem; Glutathione biosynthesis, glutamate => glutathione, organism-specific biosystem; Glutathione biosynthesis, glutamate => glutathione, conserved biosystem; |
Function | ADP binding; ATP binding; coenzyme binding; glutamate binding; glutamate-cysteine ligase activity; |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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