Recombinant Human GCA grancalcin, EF-hand Calcium Binding Protein, His-tagged

• Cat.No.: GCA-2921H
• Product Overview: Recombinant Human GCA protein was expressed in E.coli with His-tag at the N-terminus. The molecular weight is 24010 Da(217 aa).

Specification

• Cat. No.: GCA-2921H
• Description: Grancalcin is a protein that in humans is encoded by the GCA gene. grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
• Sequences of amino acids: 1-217 aa
• Formulation: 10 mM Tris. pH 8.0. 0.002% NaN3. 3mM NaCl. 2.5mM Imidazole.
• Purity: 95%

Gene Information

• Gene Name: GCA grancalcin, EF-hand calcium binding protein [ Homo sapiens ]
• Synonyms: GCL; grancalcin; OTTHUMP00000204639; OTTHUMP00000204640; grancalcin, penta-EF-hand protein; grancalcin, EF-hand calcium-binding protein
• Gene ID: 25801
• mRNA Refseq: NM_012198
• Protein Refseq: NP_036330
• MIM: 607030
• UniProt ID: P28676
• Chromosome Location: 2q37.1
• Pathway: Insulin signaling pathway; mTOR signaling pathway
• Function: calcium ion binding; protein homodimerization activity