Recombinant Human galanin/GMAP prepropeptide, His-tagged

• Cat.No.: GAL-539H
• Product Overview: GAL, 20-123aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 20-123 a.a.
• Description: Galanin peptides preproprotein, also known as GAL, is localized in brain pathways involved in both cognition and affect, and may inhibit learning and memory by inhibiting neurotransmitter release and neuronal firing rate. It modulates a variety of physiological processed including cognition/memory, sensory/pain processing, neurotransmitter/hormone secretion, and feeding behavior. GAL is upregulated in primary afferent and sympathetic neurones and may be involved in the development of sympathetic perineuronal baskets ("rings") following nerve injury. Recombinant human GAL protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
• Molecular Mass: 13.9kDa (127aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSASAGLWS PAKEKRGWTL NSAGYLLGPH AVGNHRSFSD KNGLTSKREL RPEDDMKPGS FDRSIPENNI MRTIIEFLSF LHLKEAGALD RLLDLPAAAS SEDIERS
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: GAL galanin prepropeptide [ Homo sapiens ]
• Official Symbol: GAL
• Synonyms: GAL; galanin prepropeptide; galanin , GALN; galanin peptides; galanin message associated peptide; GLNN; GMAP; galanin-related peptide; galanin-message-associated peptide; GALN; MGC40167
• Gene ID: 51083
• mRNA Refseq: NM_015973
• Protein Refseq: NP_057057
• MIM: 137035
• UniProt ID: P22466
• Chromosome Location: 11q13.2
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem
• Function: neuropeptide hormone activity