Recombinant Human GAD2, GST-tagged
Cat.No. : | GAD2-13107H |
Product Overview : | Recombinant Human GAD2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
Availability | March 14, 2025 |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Protein Length : | 1-180a.a. |
Description : | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name | GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) [ Homo sapiens ] |
Official Symbol | GAD2 |
Synonyms | GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65; GAD-65; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform; MGC161605; MGC161607; |
Gene ID | 2572 |
mRNA Refseq | NM_000818 |
Protein Refseq | NP_000809 |
MIM | 138275 |
UniProt ID | Q05329 |
Chromosome Location | 10p13-p11.2 |
Pathway | Alanine and aspartate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; GABA (gamma-Aminobutyrate) shunt, organism-specific biosystem; |
Function | carboxy-lyase activity; glutamate decarboxylase activity; lyase activity; protein binding; pyridoxal phosphate binding; |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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