Recombinant Human GAD2 Protein, MYC/DDK-tagged

• Cat.No.: GAD2-22H
• Product Overview: Recombinant protein of human glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (GAD2), transcript variant 1, was expressed in HEK293 cells.

Specification

• Description: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008].
• Source: HEK293 cells
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 65.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 µg/mL as determined by microplate BCA method.
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Protein length: 1-585 aa

Gene Information

• Gene Name: GAD2 glutamate decarboxylase 2 [ Homo sapiens (human) ]
• Official Symbol: GAD2
• Synonyms: GAD2; glutamate decarboxylase 2; GAD65; glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 65 kDa isoform; EC 4.1.1.15
• Gene ID: 2572
• mRNA Refseq: NM_000818
• Protein Refseq: NP_000809
• MIM: 138275
• UniProt ID: Q05329