Recombinant Human GABRA4 Protein, His&GST-tagged

• Cat.No.: GABRA4-1544H
• Product Overview: Recombinant Human GABRA4 Protein (Gln36-Tyr258) with N-His&GST tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: Gln36-Tyr258
• Description: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 55.8 kDa
  Accurate Molecular Mass: 66 kDa
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 [ Homo sapiens (human) ]
• Official Symbol: GABRA4
• Synonyms: GABRA4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor; alpha 4; GABA(A) receptor, alpha 4
• Gene ID: 2557
• mRNA Refseq: NM_000809
• Protein Refseq: NP_000800
• MIM: 137141
• UniProt ID: P48169