Recombinant Human GABRA1, GST-tagged

• Cat.No.: GABRA1-13092H
• Product Overview: Recombinant Human GABRA1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 20-260a.a.
• Description: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 [ Homo sapiens ]
• Official Symbol: GABRA1
• Synonyms: GABRA1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; EJM5; GABA(A) receptor; alpha 1; GABA(A) receptor, alpha 1; GABA(A) receptor subunit alpha-1; EJM; ECA4
• Gene ID: 2554
• mRNA Refseq: NM_000806
• Protein Refseq: NP_000797
• MIM: 137160
• UniProt ID: P14867
• Chromosome Location: 5q34
• Pathway: GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem
• Function: GABA-A receptor activity; chloride channel activity; drug binding; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity