Gabra1
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, alpha 1 -
Overview
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GABRA1;gamma-aminobutyric acid (GABA) A receptor, alpha 1;EJM;ECA4;EJM5;EIEE19;gamma-aminobutyric acid receptor subunit alpha-1;GABA(A) receptor, alpha 1;GABA(A) receptor subunit alpha-1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Cynomolgus
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
Gabra1 involved in several pathways and played different roles in them. We selected most pathways Gabra1 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gabra1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retrograde endocannabinoid signaling | PRKACA,GRM1,GABRG3,GRIA2,PTGS2,GABRD,GNG2,MAPK8,GNG5,GNGT2 |
| GABAergic synapse | GNB2,GABRQ,GABRA5,GAD1,SLC6A13,PRKACG,NSF,GABRG1,SLC38A2,PRKACA |
| Nicotine addiction | GABRB1,GRIN3B,GABRG2,SLC17A6,GABRQ,GRIA3,GRIN2D,GABRR1,GRIN2A,CHRNA6 |
| Neuroactive ligand-receptor interaction | P2RY14,MTNR1BB,PTGER2A,NMBR,CHRNB2,TSPO,SSTR1,TAAR8A,GRM8B,DRD4A |
Protein Function
Gabra1 has several biochemical functions, for example, contributes_to GABA receptor activity,GABA-A receptor activity,contributes_to benzodiazepine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Gabra1 itself. We selected most functions Gabra1 had, and list some proteins which have the same functions with Gabra1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chloride channel activity | SLC26A3.2,CLCNKB,GABRA6,CLCN1,GABRA4,GABRG3,BEST1,SLC26A6,GABRR3,CLCC1 |
| drug binding | SIGMAR1,DRD3,GSTP2,SRP54,P2RX4,CHRM3,PDE4D,CHRNA2,CYP2C9,HTR2C |
| inhibitory extracellular ligand-gated ion channel activity | GABRG1,GABRE,GABRA2,GABRA3,GABRA5,GABRA4,GABRG3,GABRB2,GABRA6A,GABRG2 |
| GABA-A receptor activity | GABRE,GABRZ,GABRR1,GABRB3,GABRR3,GABRD,GABRG2,GABRB2,GABRA6A,GABRR2 |
| contributes_to benzodiazepine receptor activity | GABRE,GABRG1,GABRG3,GABRA6A,GABRA5 |
Interacting Protein
Gabra1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gabra1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gabra1.
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References
- Swanson, AM; Allen, AG; et al. GABA(A)alpha 1-Mediated Plasticity in the Orbitofrontal Cortex Regulates Context-Dependent Action Selection. NEUROPSYCHOPHARMACOLOGY 40:1027-1036(2015).
- Park, YG; Choi, JH; et al. Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice. MOLECULAR BRAIN 8:-(2015).
