Recombinant Human GABARAPL2, His-tagged

• Cat.No.: GABARAPL2-489H
• Product Overview: A DNA sequence encoding the mature form of human GABARAPL2 (P60520) (Met1-Phe117) was expressed with a polyhistide tag at the N-terminus.

Specification

• Description: GATE-16, also known as ATG8, belongs to the MAP1 LC3 family. It is expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. GATE-16 is expressed at very low levels in lung, thymus and small intestine. GATE-16 is involved in intra-Golgi traffic. It modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.
• Source: Human Cell
• Species: Human
• Tag: His
• Predicted N Terminal: His
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
• Molecular Mass: The recombinant human GABARAPL2 consists of 132 amino acids and predicts a molecular mass of 15.5 KDa. It migrates as an approximately 15 KDa band in SDS-PAGE under reducing conditions.
• Endotoxin: <1.0 eu per ug protein as determined by the lal</1.0
• Purity: >95 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Protein length: 1-117 a.a.

Gene Information

• Gene Name: GABARAPL2 GABA(A) receptor-associated protein-like 2 [ Homo sapiens ]
• Official Symbol: GABARAPL2
• Synonyms: GABARAPL2; GABA(A) receptor-associated protein-like 2; gamma-aminobutyric acid receptor-associated protein-like 2; ATG8; ATG8C; GATE 16; GATE16; GEF2; ganglioside expression factor 2; MAP1 light chain 3 related protein; MAP1 light chain 3-related protein
• Gene ID: 11345
• mRNA Refseq: NM_007285
• Protein Refseq: NP_009216
• MIM: 607452
• UniProt ID: P60520
• Chromosome Location: 16q22.1
• Pathway: GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem
• Function: ATPase binding; GABA receptor binding; GABA receptor binding; SNARE binding; beta-tubulin binding; microtubule binding; protein binding