Recombinant Human G Protein-Coupled Receptor Kinase 6, GST-tagged

• Cat.No.: GRK6-1233H
• Product Overview: Recombinant humanfull length GRK6, GST-tagged. No special measures were taken to activate thiskinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: Thisgene encodes a member of the guanine nucleotide-binding protein (Gprotein)-coupled receptor kinase subfamily of the Ser/Thr protein kinasefamily. The protein phosphorylates the activated forms of G protein-coupledreceptors thus initiating their deactivation. Several transcript variantsencoding different isoforms have been described for this gene. GRK6 appearsto be involved in responses to morphine.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 94.0 kDa
• Purity: ≥ 90% as determinedby SDS-PAGE analysis
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: GRK6
• Full Length: Full L.

Gene Information

• Gene Name: GRK6 G protein-coupled receptorkinase 6 [ Homo sapiens ]
• Synonyms: GRK6; G protein-coupledreceptor kinase 6; GPRK6; FLJ32135; G protein-coupled receptor kinase 6;OTTHUMP00000223834; OTTHUMP00000223835; OTTHUMP00000223836;OTTHUMP00000231482; OTTHUMP00000231483; g protein-coupled receptor kinaseGRK6
• Gene ID: 2870
• mRNA Refseq: NM_001004105
• Protein Refseq: NP_001004105
• MIM: 600869
• UniProt ID: P43250
• Chromosome Location: 5q35
• Pathway: CXCR4-mediated signalingevents; Chemokine signaling pathway; Chemokine signaling pathway; Endocytosis;Myometrial Relaxation and Contraction Pathway
• Function: ATP binding; G-protein coupledreceptor kinase activity; nucleotide binding; signal transducer activity