Recombinant Human FUSIP1, GST-tagged

• Cat.No.: FUSIP1-13038H
• Product Overview: Recombinant Human FUSIP1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 8-183a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: SRSF10 serine/arginine-rich splicing factor 10 [ Homo sapiens ]
• Official Symbol: SRSF10
• Synonyms: SRSF10; serine/arginine-rich splicing factor 10; FUS interacting protein (serine/arginine rich) 1 , FUS interacting protein (serine arginine rich) 2 , FUSIP1, FUSIP2, neural salient SR protein , SFRS13A, splicing factor, arginine/serine rich 13A; NSSR; SFRS13; splicing factor; arginine/serine rich 13; SR splicing factor 10; SRp38; SRrp40; TASR1; TASR2; splicing factor SRp38; TLS-associated SR protein; neural-salient SR protein; 40 kDa SR-repressor protein; TLS-associated protein TASR; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; splicing factor, arginine/serine-rich 13; splicing factor, arginine/serine-rich 13A; serine-arginine repressor protein (40 kDa); TLS-associated protein with Ser-Arg repeats; FUS-interacting serine-arginine-rich protein 1; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; TASR; FUSIP1; FUSIP2; SFRS13A; FLJ30749; FLJ43846; DKFZp686H0644
• Gene ID: 10772
• mRNA Refseq: NM_001191005
• Protein Refseq: NP_001177934
• MIM: 605221
• UniProt ID: O75494
• Chromosome Location: 1p36.11
• Pathway: Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem; mRNA processing, organism-specific biosystem
• Function: RNA binding; RS domain binding; nucleic acid binding; nucleotide binding; protein binding; unfolded protein binding