Recombinant Human Fructose-1,6-bisphosphatase 1, His-tagged

• Cat.No.: FBP1-1815H
• Product Overview: Recombinant human FBP1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 39.0 kDa (358aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Fructose-1,6-bisphosphatase 1(FBP1) is a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT 10% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: FBP1 fructose-1,6-bisphosphatase 1 [ Homo sapiens ]
• Synonyms: FBP1; fructose-1,6-bisphosphatase 1; FBP; FBPase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; EC 3.1.3.11; OTTHUMP00000021694
• Gene ID: 2203
• mRNA Refseq: NM_000507
• Protein Refseq: NP_000498
• MIM: 611570
• UniProt ID: P09467
• Chromosome Location: 9q22.3
• Pathway: Fructose and mannose metabolism; Glycolysis / Gluconeogenesis; Insulin signaling pathway; Metabolic pathways; Pentose phosphate pathway
• Function: fructose 1,6-bisphosphate 1-phosphatase activity; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; identical protein binding; magnesium ion binding; monosaccharide binding; phosphoric ester hydrolase activity