FBP1

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    fructose-1,6-bisphosphatase 1
  • Overview

    Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
  • Synonyms

    FBP1;fructose-1,6-bisphosphatase 1;FBP;6-bisphosphatase 1;6-bisphosphate 1-phosphohydrolase 1;D fructose 1 6 bisphosphate 1 phosphohydrolase 1;D-fructose-1;EC 3.1.3.11;F16P1_HUMAN;FBP 1;FBPase 1;Fructose 1 6 bisphosphatase 1;Fructose bisphosphatase 1;Fructose-1;Growth inhibiting protein 17;Liver fructose bisphosphatase;OTTHUMP00000021694;fructose-bisphosphatase 1;growth-inhibiting protein 17;D-fructose-1,6-bisphosphate 1-phosphohydrolase 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • Myc
  • SUMO
  • GST
  • Non
  • DDK
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
FBP1-389H Active Recombinant Human FBP1 Protein, His-tagged E.coli Human His
FBP1-1065H Recombinant Human FBP1 Mammalian Cells Human His
FBP1-1207H Recombinant Human FBP1 Protein, His-SUMO/MYC-tagged E.coli Human His&Myc&SUMO 2-338 a.a.
FBP1-1651R Recombinant Rhesus monkey FBP1 Protein, His-tagged Mammalian Cells Rhesus macaque His
FBP1-1815H Recombinant Human Fructose-1,6-bisphosphatase 1, His-tagged E.coli Human His
FBP1-2283R Recombinant Rat FBP1 Protein Mammalian Cells Rat His
FBP1-28810TH Recombinant Human FBP1, His-tagged E.coli Human His Full L. 1-338 a.a.
FBP1-3880H Recombinant Human FBP1 Protein, GST-tagged Wheat Germ Human GST
FBP1-5329C Recombinant Chicken FBP1 Mammalian Cells Chicken His
FBP1-5707M Recombinant Mouse FBP1 Protein Mammalian Cells Mouse His
FBP1-787H Recombinant Human FBP1 Protein, GST-tagged E.coli Human GST 2-338 a.a.
FBP1-788H Recombinant Human FBP1 Protein, His-tagged HEK293 Human His
FBP1-6316HCL Recombinant Human FBP1 293 Cell Lysate HEK293 Human Non
Fbp1-1025M Recombinant Mouse Fbp1 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
FBP1-1467H Recombinant Human FBP1 Protein, His&GST-tagged E.coli Human GST&His Met1-Gln338
FBP1-1475R Recombinant Rhesus Macaque FBP1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
FBP1-1475R-B Recombinant Rhesus Macaque FBP1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
FBP1-1940R Recombinant Rat FBP1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
FBP1-1940R-B Recombinant Rat FBP1 Protein Pre-coupled Magnetic Beads HEK293 Rat
FBP1-2335H Recombinant Human FBP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
FBP1-2427H Recombinant Human FBP1 Protein (Ala2-Gln338), C-His tagged E.coli Human His Ala2-Gln338
FBP1-2428H Recombinant Human FBP1 Protein (Met1-Gln338), His tagged E.coli Human His Met1-Gln338
FBP1-2887H Recombinant Human FBP1 protein, His&Myc-tagged E.coli Human His&Myc 2-338aa
FBP1-3136M Recombinant Mouse FBP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
FBP1-3136M-B Recombinant Mouse FBP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
FBP1-4248H Recombinant Human FBP1 protein, GST-tagged E.coli Human GST 1-338aa
FBP1-4896HF Recombinant Full Length Human FBP1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 338 amino acids
FBP1-6554H Recombinant Human FBP1 protein, His-tagged E.coli Human His 353aa(including fusion tag)
FBP1-863HFL Recombinant Full Length Human FBP1 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
FBP1-894H Recombinant Human FBP1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
FBP1-894H-B Recombinant Human FBP1 Protein Pre-coupled Magnetic Beads HEK293 Human

Background

What is FBP1 protein?

FBP1 (fructose-bisphosphatase 1) gene is a protein coding gene which situated on the long arm of chromosome 9 at locus 9q22. Fructose-1,6-bisphosphatase 1(FBP1) is a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. The FBP1 protein is consisted of 338 amino acids and its molecular mass is approximately 36.8 kDa.

What is the function of FBP1 protein?

FBP1 appears to modulate glycerol gluconeogenesis in liver. It is an important regulator of appetite and adiposity. The expression of FBP1 in liver will increase after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus it seems to provide a feedback mechanism to limit weight gain.

FBP1-7.jpg

Fig1. A schematic diagram illustrates how reduced FBP1 expression upon irradiation leads to glycolysis activation and infiltration of glioblastoma (GBM). (Beomseok Son, 2019)

FBP1 Related Signaling Pathway

The signaling pathways involved in FBP1 (fructose-1, 6-diphosphatase) are gluconeogenesis and glycolysis. In addition, the activity of FBP1 is regulated by many factors, including AMP, Insulin, PPARα, etc. PPARα is a nuclear receptor whose activation can inhibit FBP1 transcription. AMPK is an energy-sensitive kinase whose activity is regulated by changes in the intracellular AMP/ATP ratio. Activated AMPK can inhibit the expression and activity of FBP1, thereby reducing gluconeogenesis.

FBP1 Related Diseases

FBP1 is mainly involved in the metabolic process of glucose. If the function of this enzyme is abnormal, or the expression of FBP1 is low, it is associated with hypoglycemia and metabolic acidosis. And it may affect the normal metabolism of glucose, which may lead to a series of metabolic diseases, such as diabetes and obesity. Other related diseases include glycogen storage disease type I (GSD-I), hepatic insulin resistance and hepatocellular carcinoma (HCC).

Bioapplications of FBP1

FBP1 is widely used in biology, involving many fields such as glucose metabolism, diabetes, drug research and development. By further studying the function and regulatory mechanism of FBP1, we can provide new ideas and methods for the prevention, diagnosis and treatment of related diseases.

Case Study

Case Study 1: Alexander Damanakis, 2022

FBP1-3.jpg

Fig1. Representative images of immunohistochemistry (IHC) from A FBP1-negative (score 0) and B FBP1-positive (score 3) specimens of esophageal adenocarcinoma from the tissue microarray.

Case Study 2: Bo Wang, 2020

FBP1-4.jpg

Fig2. MCF-7, T47D, VCaP and PC-3 cells were harvested for western blot after infected with lentivirus expressing control shRNA or FBP1-specific shRNA.

Quality Guarantee

Involved Pathway

FBP1 involved in several pathways and played different roles in them. We selected most pathways FBP1 participated on our site, such as Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fructose and mannose metabolism PFKP,PFKFB4,FBP2,KHK,AKR1B7,PFKMB,DHRS13L1,ALDOC,FBP1B,HK1
AMPK signaling pathway RPS6KB2,CREB3L4,PIK3CG,CRTC2,CAB39L,PRKAA2,PIK3R1,CREB3L2,RAB10,RPTOR
Insulin signaling pathway HRASA,TRIP10,EIF4E1B,IRS2,GRB2,PDPK1,TSC1B,TSC1A,ARAF,PIK3CA
Carbon metabolism ENO1A,pykF,TPI1,ESD,PKM,ECHS1,ALDOCA,HK3,SUCLG2,PKMB
Pentose phosphate pathway PFKMA,PRPS1,ALDOAA,PGLS,PRPS1A,G6PD,PFKM,FBP1A,PGM1,ALDOCA
Metabolic pathways AMY2A4,PAPSS2B,ALDOA,NAT2,ST6GAL1,MTMR2,NAPRT,IDO1,AGPAT5,PSPH
Glycolysis / Gluconeogenesis ADH6,HK3,ENO3,HKDC1,PGM2,ADH4,PGAM2,pykF,AKR1A1B,G6PC3

FBP1-6.jpg

Fig2. A hypothetical model depicting FBP1 repression of PD-L1 expression via the competitive interaction with STAT3. (Bo Wang, 2020)

Protein Function

FBP1 has several biochemical functions, for example, AMP binding,fructose 1,6-bisphosphate 1-phosphatase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBP1 itself. We selected most functions FBP1 had, and list some proteins which have the same functions with FBP1. You can find most of the proteins on our site.

Function Related Protein
fructose 1,6-bisphosphate 1-phosphatase activity FBP1A,FBP2,FBP1B
AMP binding PRPS1,PRPS2,PRKAG2,PRKAG1,CYB5R3,APRT,ACSS2,PYGM,ACSS1,PYGL
metal ion binding ZFP36L2,DYRK4,COL9A1,ZNF791,ZNF37A,RIOK3,NEK2,SEMG2,CYP2V1,GUCA1D
monosaccharide binding PGLS,UPK1A,RPIA,GPR19,Siglece,TALDO1,GPI,GPI1
identical protein binding FNBP1,MYD88,CIDEB,COIL,ESYT2,KIRRELA,TPRGL,SAFB2,TRIM21,PARK2
protein binding SRC,SORL1,ALKBH6,TRIM27,ZCCHC17,GSTO2,DROSHA,EID3,FAM108A1,ALOX12B

Interacting Protein

FBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBP1.

BIN1;FBP2;ACTN3;DYNC1I1;BUB1;TLR2

Resources

References

  • Orino, K; Ishiji, T; et al. Characterization of bovine serum ferritin-binding proteins. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 137:375-381(2004).
  • Viudes, A; Perea, S; et al. Identification of continuous B-cell epitopes on the protein moiety of the 58-kilodalton cell wall mannoprotein of Candida albicans belonging to a family of immunodominant fungal antigens. INFECTION AND IMMUNITY 69:2909-2919(2001).

Ask a Question for All FBP1 Products

Required fields are marked with *

My Review for All FBP1 Products

Required fields are marked with *