Recombinant Human FOXO3

• Cat.No.: FOXO3-28110TH
• Product Overview: Recombinant full length Human FOXO3A with an N terminal proprietary tag; Predicted MWt 100.1 kDa inclusive of tag.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 673 amino acids
• Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
• Molecular Weight: 100.100kDa inclusive of tags
• Tissue specificity: Ubiquitous.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPEL QASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIG GGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLS GGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNL SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDS NSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDG GKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPES ADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTV SGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSK PCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQ PSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSL NSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLS HSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFA AQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLS ESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLP VMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDF NFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
• Sequence Similarities: Contains 1 fork-head DNA-binding domain.

Gene Information

• Gene Name: FOXO3 forkhead box O3 [ Homo sapiens ]
• Official Symbol: FOXO3
• Synonyms: FOXO3; forkhead box O3; FKHRL1, FOXO3A; forkhead box protein O3; AF6q21; FOXO2
• Gene ID: 2309
• mRNA Refseq: NM_001455
• Protein Refseq: NP_001446
• MIM: 602681
• Uniprot ID: O43524
• Chromosome Location: 6q21
• Pathway: AKT phosphorylates targets in the nucleus, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; Class I PI3K signaling events mediated by Akt, organism-specific biosystem
• Function: DNA bending activity; double-stranded DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding