Recombinant Human Fms-Related Tyrosine Kinase 3

• Cat.No.: FLT3-1225H
• Product Overview: Recombinant humanFLT3 is Expressed in HEK 293 cells.

Specification

• Cat. No.: FLT3-1225H
• Description: FLT3 Ligand is expressed from human 293cells as a monomeric glycoprotein with an apparent MW 24 to 30 kDa. Thiscytokine is produced in a serum-free, chemically defined media. The molecularmass is a narrower range than reported when this cytokine is expressed ininsect Sf21 cells (17 to 30 kDa), emphasizing the difference in glycosylationin different expression systems.
• Source: HEK 293 cells
• Species: Human
• MolecularWeight: 24 to 30 kDamonomer, glycosylated
• Purity: > 95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
• Endotoxin Level: Endotoxin Free <1EU/ug
• Biological Activity: 0.2 to 0.8 ng/mLED50
• Storage: The specificactivity was determined by the dose-dependent stimulation of theproliferation of the human acute myeloid leukemia cell line OCI-AML5.
• Tag: Non

Gene Information

• Gene Name: FLT3 fms-related tyrosine kinase 3 [ Homosapiens ]
• Official Symbol: FLT3
• Synonyms: FLT3; fms-related tyrosinekinase 3; FLK2; STK1; CD135; CD135 antigen; fetal liver kinase 2; FL cytokinereceptor; tal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptortyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factorreceptor tyrosine kinase type III; C 2.7.10.1; OTTHUMP00000042340; fetalliver kinase 2
• Gene ID: 2322
• mRNA Refseq: NM_004119
• Protein Refseq: NP_004110
• MIM: 136351
• UniProt ID: P36888
• Chromosome Location: 13q12
• Pathway: Acute myeloidleukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage;Pathways in cancer
• Function: ATP binding; nucleotidebinding; osphoinositide 3-kinase binding; protein binding; receptor activity;transferase activity; vascular endothelial growth factor receptor activity

Reviews

08/01/2021

Excellent product, great price.

12/22/2020

Satisfied, will order again.

09/14/2020

Quick response, helpful service.

Q&As

How is FLT3 implicated in acute myeloid leukemia (AML)?

FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

In which cells or tissues is FLT3 predominantly expressed?

FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

How does FLT3 contribute to hematopoiesis?

It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

Are there therapeutic strategies targeting FLT3 for disease treatment?

Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

What is the primary biological function of FLT3 in cells?

FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells?

It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

What are the common mutations found in FLT3 associated with diseases?

Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.