Recombinant Human FLT3 protein, His-tagged

• Cat.No.: FLT3-6334H
• Product Overview: Recombinant Human FLT3 protein(P36888)(564-958aa), fused with C-terminal His tag, was expressed in Insect cells.

Specification

• Source: Insect cells
• Species: Human
• Tag: C-His
• Protein length: 564-958aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 48.5 kDa
• AASequence: HKYKKQFRYESQLQMVQVTGSSDNE YFYVDFREYEYDLKWEFPRENLEFG KVLGSGAFGKVMNATAYGISKTGVS IQVAVKMLKEKADSSEREALMSELK MMTQLGSHENIVNLLGACTLSGPIY LIFEYCCYGDLLNYLRSKREKFHRT WTEIFKEHNFSFYPTFQSHPNSSMP GSREVQIHPDSDQISGLHGNSFHSE DEIEYENQKRLEEEEDLNVLTFEDL LCFAYQVAKGMEFLEFKSCVHRDLA ARNVLVTHGKVVKICDFGLARDIMS DSNYVVRGNARLPVKWMAPESLFEG IYTIKSDVWSYGILLWEIFSLGVNP YPGIPVDANFYKLIQNGFKMDQPFY ATEEIYIIMQSCWAFDSRKRPSFPN LTSFLGCQLADAEEAMYQNV
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
• Official Symbol: FLT3
• Synonyms: FLT3; fms-related tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; CD135; FLK2; STK1; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; FLK-2
• Gene ID: 2322
• mRNA Refseq: NM_004119
• Protein Refseq: NP_004110
• MIM: 136351
• UniProt ID: P36888

Reviews

08/01/2021

Excellent product, great price.

12/22/2020

Satisfied, will order again.

09/14/2020

Quick response, helpful service.

Q&As

How is FLT3 implicated in acute myeloid leukemia (AML)?

FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

In which cells or tissues is FLT3 predominantly expressed?

FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

How does FLT3 contribute to hematopoiesis?

It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

Are there therapeutic strategies targeting FLT3 for disease treatment?

Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

What is the primary biological function of FLT3 in cells?

FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells?

It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

What are the common mutations found in FLT3 associated with diseases?

Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.