Recombinant Human FKBP5, MYC/DDK-tagged

• Cat.No.: FKBP5-8372H
• Product Overview: Recombinant Human FKBP5, transcript variant 1, fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 51 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: FKBP5 FK506 binding protein 5 [ Homo sapiens ]
• Official Symbol: FKBP5
• Synonyms: P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10; peptidyl-prolyl cis-trans isomerase FKBP5; 51 kDa FK506-binding protein; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; FF1 antigen; FKBP-51; HSP90-binding immunophilin; PPIase FKBP5; T-cell FK506-binding protein; androgen-regulated protein 6; peptidylprolyl cis-trans isomerase; rotamase
• Gene ID: 2289
• mRNA Refseq: NM_004117
• Protein Refseq: NP_004108
• MIM: 602623
• UniProt ID: Q13451
• Chromosome Location: 6p21.31
• Pathway: Estrogen signaling pathway, organism-specific biosystem; Estrogen signaling pathway, conserved biosystem; Prostate Cancer, organism-specific biosystem
• Function: FK506 binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity