Recombinant Human FKBP2

• Cat.No.: FKBP2-28913TH
• Product Overview: Recombinant Human full-length mature FKBP2, amino acids 22-142, predicted MWt 13.4 kDa.

Specification

• Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Protein length: 121 amino acids
• Molecular Weight: 13.400kDa
• Source: E. coli
• Tissue specificity: T-cells and thymus.
• Biological activity: Specific activity is >150 nmoles/min/ug, and is defined as the amount of enzyme that cleave 1umole of suc-AAFP-pNA per minute at 1C in Tris-Hcl pH8.0 using chymotrypsin.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.32% Tris HCl, 0.02% DTT
• Storage: Please see Notes section
• Sequences of amino acids: MATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL.
• Sequence Similarities: Belongs to the FKBP-type PPIase family. FKBP2 subfamily.Contains 1 PPIase FKBP-type domain.
• Tag: Non

Gene Information

• Gene Name: FKBP2 FK506 binding protein 2, 13kDa [ Homo sapiens ]
• Official Symbol: FKBP2
• Synonyms: FKBP2; FK506 binding protein 2, 13kDa; FK506 binding protein 2 (13kD); peptidyl-prolyl cis-trans isomerase FKBP2; FKBP 13; peptidyl prolyl cis trans isomerase; PPIase; proline isomerase; rapamycin binding protein
• Gene ID: 2286
• mRNA Refseq: NM_001135208
• Protein Refseq: NP_001128680
• MIM: 186946
• Uniprot ID: P26885
• Chromosome Location: 11q13.1-q13.3
• Function: FK506 binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding