Recombinant Human FGFRL1, His-tagged

• Cat.No.: FGFRL1-7704H
• Product Overview: Recombinant Human Fibroblast Growth Factor ReceptorLike 1/FGFRL1 produced by transfected human cell is a secreted protein with sequence (Ala25Pro378) of Human FGFRL1 fused with a polyhistidine tag at the Cterminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: Fibroblast Growth Factor ReceptorLike 1 (FGFRL1) is a singlepass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consists of a 354 amino acid extracellular domain (ECD) with 3 Iglike C2type domains, a 21 amino acid transmembrane segment, and a 134 amino acid cytoplasmic domain. FGFR1 expressed in various tissues, preferentially in cartilaginous tissues and pancreas. It highly expressed in the liver, kidney, heart, brain and skeletal muscle, weakly expressed in the lung, small intestine and spleen. FGFRL1 has a negative effect on cell proliferation.
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0
• AA Sequence: ARGPPKMADK VVPRQVARLG RTVRLQCPVE GDPPPLTMWT KDGRTIHSGW SRFRVLPQGL KVKQVERED AGVYVCKATN GFGSLSVNYT LVVLDDISPG KESLGPDSSS GGQEDPASQQ W ARPRFTQP SKMRRRVIAR PVGSSVRLKC VASGHPRPDI TWMKDDQALT RPEAAEPRKK KW TLSLKNL RPEDSGKYTC RVSNRAGAIN ATYKVDVIQR TRSKPVLTGT HPVNTTVDFG GTT SFQCKV RSDVKPVIQW
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: FGFRL1 fibroblast growth factor receptor-like 1 [ Homo sapiens ]
• Official Symbol: FGFRL1
• Synonyms: FGFRL1; fibroblast growth factor receptor-like 1; FGFR-5; FGFR-like protein; FGF receptor-like protein 1; FGF homologous factor receptor; fibroblast growth factor receptor 5; FHFR; FGFR5
• Gene ID: 53834
• mRNA Refseq: NM_001004356
• Protein Refseq: NP_001004356
• MIM: 605830
• UniProt ID: Q8N441
• Chromosome Location: 4p16
• Function: fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; heparin binding; receptor activity